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Neuroinflammation, Chronic Stress, Traumatic Brain Injury and Diseases
What Do We Know About Neuroinflammation?
Neuroinflammation is an inflammation of the central nervous system (CNS). It can lead to neuronal injury and dysfunction.
What is Integrative and Functional Medicine?
Integrative and Functional Medicine Prescribers often take special interest treating and preventing inflammation.
Traumatic Brain Injury
- NFL players with concussions (as well as many other sports)
- Military people such as Navy Seals after being in combat zones
- Motor Vehicle Accidents
- Electric Shock
- Violence Injury
Disease
- Diabetes
- Parkinson’s
- Alzheimer’s (Dementia)
- Autism Spectrum Disorder
- ADHD
- Autoimmune Diseases
- ALS (Lou Gehrig’s Disease)
- Lyme Disease
- Mold
- Stroke /TIA’s
Chronic Stress Situations
- Executive Burnout
- Career stress—see an example of racecar drivers
- Lifestyle stress- money, marriage, kids
- Overloaded parents with “jello brain”
What Can Lead to Neuroinflammation?
- Traumatic brain injuries (Concussions, motor vehicle accidents, injury from violence)
- Autoimmune diseases
- By-products of diseases- circulating endotoxins
- Microglial activation- different components to inflammation are led by microglial cells
- Chronic stress- Chronic stress involves elevated cortisol which can lead to microglial activation via the release of inflammatory cytokines. In other words, stress often causes chronic inflammation which can lead to neuronal injury or death and therefore changes in behavior. It interferes with all stages of neuronal renewal.
Stress causes people to feel scattered and feeling like they can’t think straight. They often wonder what is happening to them.
How can we quiet that brain cell activation which leads to inflammation? According to Dr James LaValle, RG3 and Nicotinamide Riboside may help.
Why don’t we try to prevent inflammation and disease before they occur?
*There are various practitioners who focus on this aspect of medicine.
Methylcobalamin (RG3-Synapsin®) Spray
Methylcobalamin (RG3-Synapsin®) Spray (RG3 + Nicotinamide Riboside + Methyl B12) is an innovative, patent-pending powder blend of ginsenoside Rg3 and nicotinamide riboside along with
ingredients to aid in solubilization and dispersion. It is designed to be used in formulations for the support of neurological health and cognitive support.
Methylcobalamin (RG3-Synapsin®) was invented by renowned author, pharmacist and functional medicine speaker Jim LaValle, RPh, CCN, ND, and is commonly used in combination with methylcobalamin or hydroxocobalamin in formulations to support neuronal function and cognition.
Low Dose Naltrexone (LDN)
Read about the mechanism in which low dose naltrexone LDN works to reduce inflammation.
Abstract Low-dose naltrexone (LDN) has been demonstrated to reduce symptom severity in conditions such as fibromyalgia, Crohn’s disease, multiple sclerosis, and complex regional pain syndrome. We review the evidence that LDN may operate as a novel anti-inflammatory agent in the central nervous system, via action on microglial cells. These effects may be unique to low dosages of naltrexone and appear to be entirely independent from naltrexone’s better-known activity on opioid receptors. As a daily oral therapy, LDN is inexpensive and well-tolerated. Despite initial promise of efficacy, the use of LDN for chronic disorders is still highly experimental. Published trials have low sample sizes, and few replications have been performed. We cover the typical usage of LDN in clinical trials, caveats to using the medication, and recommendations for future research and clinical work. LDN may represent one of the first glial cell modulators to be used for the management of chronic pain disorders.
What is Low Dose Naltrexone (LDN)?
Naltrexone belongs to a class of drugs known as opioid antagonists. Naltrexone blocks opiate drugs from binding to the opioid receptors, which can result in increased endorphin and enkephalin release. Therefore, this results in reduced: 1. signaling and release of inflammatory substances, 2. nerve cell inflammation and 3. autoimmune mediators.