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Semaglutide Injection Solution
What is Semaglutide and how does it work?
Semaglutide is in a class of medications called glucagon-like peptide 1 (GLP-1) agonists. GLP-1 agonists work by stimulating the pancreas to increase the release of insulin. This additional insulin causes the stomach to empty over an extended period of time.
The slow emptying of the stomach is one of the first steps in a chain reaction that makes semaglutide effective. The GLP-1 receptors that are present in several regions of the brain receive signals of “being Full”. This signal is sent throughout the day, even when eating decreased calories. This is known as appetite suppression effect based on the patients’ own natural insulin production.
Semaglutide will lead to healthier blood sugar levels, leaving the patient feeling more energetic throughout their day. Dedication to healthy lifestyle choices is necessary for long-term weight management.
Indication and Usage:
Semaglutide is indicated for chronic weight management as an adjunct to a reduced calorie meal plan and increased physical activity for those who are considered obese (BMI ≥30kg/m2) or overweight (BMI ≥27kg/m2) with at least one weight-related comorbidity conditions like type 2 diabetes, hypertension, or dyslipidemia. Semaglutide is not recommended for females and males of reproductive potential and the use should be discontinued at least 2 months before a planned pregnancy. Semaglutide is a long-acting prescription medication meant to be used over an extended period of several months.
Semaglutide should not be used with any semaglutide-containing products or any other GLP-1 receptor agonists. Use of other weight loss products including over the counter medications, or any herbal preparations are discouraged in combination with semaglutide.
Dosage and Administration:
Semaglutide is a potent medication, and it is extremely important to adhere to the prescribed dosing schedules. Your body needs time to adjust to the medication. It is not a race to get to the last dosing. If your patient needs to stay at a lower dose, then that is acceptable.
Semaglutide 2mg/mL Inj. Solution
Weeks 1-4: Inject 0.125mL Subcutaneously once weekly
Weeks 5-8: Inject 0.25mL Subcutaneously once weekly
Weeks 9-12: Inject 0.5mL Subcutaneously once weekly
Semaglutide 5mg/mL Inj. Solution
Weeks 13-16: Inject 0.34mL Subcutaneously once weekly
Weeks 17 & Thereafter: Inject 0.48mL Subcutaneously once weekly
Semaglutide is administered subcutaneously in the abdomen, thigh, or upper arm once weekly on the same day each week, at any time of the day with or without food. Do not inject intramuscularly or intravenously. Rotate the sites of injection weekly and do not inject into an area where the skin is tender, swollen, bruised, red or hard. Avoid injecting into areas with scars or stretch marks.
Missed Dose: If a dose is missed, you may administer the missed dose as soon as possible, as long as the next scheduled dose is more than 2 days (48 hrs away). If the next scheduled dose is less than 2 days away, do NOT administer the missed dose and continue with the regular dosing schedule. If more than 2 doses are missed, you may continue the dosing schedule or restart the titration schedule if needed to avoid GI Symptoms.
Contraindications: Use of semaglutide is contraindicated with any personal or family history of –
• Medullary Thyroid Carcinoma (MCT)
• Multiple Endocrine Neoplasia Syndrome Type 2 (MEN 2)
• Any hypersensitivity reaction to previous use of semaglutide
• Anaphylaxis or Angioedema
• Discontinue if pregnancy occurs
Drug Interactions: Semaglutide decreases appetite by delaying gastric emptying and has the potential to affect the absorption of oral medications that are co-administered. Patients who have a known slow gastric emptying should avoid semaglutide. Concomitant Use with an Insulin Secretagogue (e.g., Sulfonylurea) or with Insulin
Warnings & Precautions:
1. Risk of Thyroid C-Cell Tumors (A mass in the neck, dysphagia, dyspnea, or persistent hoarseness)
2. Acute Pancreatitis (Severe and persistent abdominal pain, may or may not have nausea)
3. Acute gallbladder disease
4. Hypoglycemia especially with the use of other diabetic medications like sulfonylureas and insulin
5. Acute kidney injury
6. Hypersensitivity
7. Heart Rate Increase
8. Suicidal behavior and ideation
Adverse Reactions:
• Nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, dyspepsia, dizziness, abdominal distension, eructation, hypoglycemia in patients with type 2 diabetes, flatulence, gastroenteritis, gastroesophageal reflux disease, and nasopharyngitis